Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated COL1A1 Gene in Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a genetic disease characterized by bone fragility and repeated fractures. The bone fragility associated with OI is caused by a defect in collagen formation due to mutation of COL1A1 or COL1A2. Current strategies for treating OI are not curative. In this study, we gene...

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Detalles Bibliográficos
Autores principales: Jung, Hyerin, Rim, Yeri Alice, Park, Narae, Nam, Yoojun, Ju, Ji Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307903/
https://www.ncbi.nlm.nih.gov/pubmed/34300306
http://dx.doi.org/10.3390/jcm10143141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307903/
https://www.ncbi.nlm.nih.gov/pubmed/34300306
http://dx.doi.org/10.3390/jcm10143141

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