Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank

We use UK Biobank data to train predictors for 65 blood and urine markers such as HDL, LDL, lipoprotein A, glycated haemoglobin, etc. from SNP genotype. For example, our Polygenic Score (PGS) predictor correlates ∼0.76 with lipoprotein A level, which is highly heritable and an independent risk facto...

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Detalles Bibliográficos
Autores principales: Widen, Erik, Raben, Timothy G., Lello, Louis, Hsu, Stephen D. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308062/
https://www.ncbi.nlm.nih.gov/pubmed/34209487
http://dx.doi.org/10.3390/genes12070991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308062/
https://www.ncbi.nlm.nih.gov/pubmed/34209487
http://dx.doi.org/10.3390/genes12070991

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