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Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women

The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal...

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Autores principales: Trius-Soler, Marta, Marhuenda-Muñoz, María, Laveriano-Santos, Emily P., Martínez-Huélamo, Miriam, Sasot, Gemma, Storniolo, Carolina E., Estruch, Ramon, Lamuela-Raventós, Rosa M., Tresserra-Rimbau, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308431/
https://www.ncbi.nlm.nih.gov/pubmed/34209273
http://dx.doi.org/10.3390/nu13072278
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author Trius-Soler, Marta
Marhuenda-Muñoz, María
Laveriano-Santos, Emily P.
Martínez-Huélamo, Miriam
Sasot, Gemma
Storniolo, Carolina E.
Estruch, Ramon
Lamuela-Raventós, Rosa M.
Tresserra-Rimbau, Anna
author_facet Trius-Soler, Marta
Marhuenda-Muñoz, María
Laveriano-Santos, Emily P.
Martínez-Huélamo, Miriam
Sasot, Gemma
Storniolo, Carolina E.
Estruch, Ramon
Lamuela-Raventós, Rosa M.
Tresserra-Rimbau, Anna
author_sort Trius-Soler, Marta
collection PubMed
description The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal symptoms, we evaluated if a daily moderate consumption of beer with (AB) and without alcohol (NAB) could improve menopausal symptoms and modify cardiovascular risk factors. A total of 37 postmenopausal women were enrolled in a parallel controlled intervention trial and assigned to three study groups: 16 were administered AB (330 mL/day), 7 NAB (660 mL/day), and 14 were in the control group. After a 6-month follow-up of the 34 participants who finished the trial, both interventions (AB and NAB) significantly reduced the severity of the menopause-related symptoms (p-value AB vs. Control: 0.009; p-value NAB vs. Control: 0.033). Moreover, AB had a beneficial net effect on psychological menopausal discomforts compared to the control group. As the sex hormone profile did not differ significantly between the study groups, the effects of both types of beers (AB and NAB) are attributed to the non-alcoholic fraction of beer. Furthermore, moderate NAB consumption improved the lipid profile and decreased blood pressure in postmenopausal women.
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spelling pubmed-83084312021-07-25 Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women Trius-Soler, Marta Marhuenda-Muñoz, María Laveriano-Santos, Emily P. Martínez-Huélamo, Miriam Sasot, Gemma Storniolo, Carolina E. Estruch, Ramon Lamuela-Raventós, Rosa M. Tresserra-Rimbau, Anna Nutrients Article The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal symptoms, we evaluated if a daily moderate consumption of beer with (AB) and without alcohol (NAB) could improve menopausal symptoms and modify cardiovascular risk factors. A total of 37 postmenopausal women were enrolled in a parallel controlled intervention trial and assigned to three study groups: 16 were administered AB (330 mL/day), 7 NAB (660 mL/day), and 14 were in the control group. After a 6-month follow-up of the 34 participants who finished the trial, both interventions (AB and NAB) significantly reduced the severity of the menopause-related symptoms (p-value AB vs. Control: 0.009; p-value NAB vs. Control: 0.033). Moreover, AB had a beneficial net effect on psychological menopausal discomforts compared to the control group. As the sex hormone profile did not differ significantly between the study groups, the effects of both types of beers (AB and NAB) are attributed to the non-alcoholic fraction of beer. Furthermore, moderate NAB consumption improved the lipid profile and decreased blood pressure in postmenopausal women. MDPI 2021-06-30 /pmc/articles/PMC8308431/ /pubmed/34209273 http://dx.doi.org/10.3390/nu13072278 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trius-Soler, Marta
Marhuenda-Muñoz, María
Laveriano-Santos, Emily P.
Martínez-Huélamo, Miriam
Sasot, Gemma
Storniolo, Carolina E.
Estruch, Ramon
Lamuela-Raventós, Rosa M.
Tresserra-Rimbau, Anna
Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women
title Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women
title_full Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women
title_fullStr Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women
title_full_unstemmed Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women
title_short Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women
title_sort moderate consumption of beer (with and without ethanol) and menopausal symptoms: results from a parallel clinical trial in postmenopausal women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308431/
https://www.ncbi.nlm.nih.gov/pubmed/34209273
http://dx.doi.org/10.3390/nu13072278
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