Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential

Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signal...

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Detalles Bibliográficos
Autores principales: Narożna, Maria, Krajka-Kuźniak, Violetta, Bednarczyk-Cwynar, Barbara, Kucińska, Małgorzata, Kleszcz, Robert, Kujawski, Jacek, Piotrowska-Kempisty, Hanna, Plewiński, Adam, Murias, Marek, Baer-Dubowska, Wanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308582/
https://www.ncbi.nlm.nih.gov/pubmed/34358114
http://dx.doi.org/10.3390/ph14070688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308582/
https://www.ncbi.nlm.nih.gov/pubmed/34358114
http://dx.doi.org/10.3390/ph14070688

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