Cargando…

Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential

Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Narożna, Maria, Krajka-Kuźniak, Violetta, Bednarczyk-Cwynar, Barbara, Kucińska, Małgorzata, Kleszcz, Robert, Kujawski, Jacek, Piotrowska-Kempisty, Hanna, Plewiński, Adam, Murias, Marek, Baer-Dubowska, Wanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308582/ https://www.ncbi.nlm.nih.gov/pubmed/34358114 http://dx.doi.org/10.3390/ph14070688

Ejemplares similares

The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells
por: Narożna, Maria, et al.
Publicado: (2020)

Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells
por: Narożna, Maria, et al.
Publicado: (2022)

Unlocking the Potential: Novel NSAIDs Hybrids Unleash Chemopreventive Power toward Liver Cancer Cells through Nrf2, NF-κB, and MAPK Signaling Pathways
por: Narożna, Maria, et al.
Publicado: (2023)

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
por: Cykowiak, Marta, et al.
Publicado: (2021)

Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
por: Baer-Dubowska, Wanda, et al.
Publicado: (2021)

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds
por: Cykowiak, Marta, et al.
Publicado: (2021)

(+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells
por: Krajka-Kuźniak, Violetta, et al.
Publicado: (2021)

Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?
por: Krajka-Kuźniak, Violetta, et al.
Publicado: (2021)

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
por: Papierska, Katarzyna, et al.
Publicado: (2021)

The effect of resveratrol and its methylthio-derivatives on EGFR and Stat3 activation in human HaCaT and A431 cells
por: Cichocki, Michal, et al.
Publicado: (2014)

The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes
por: Krajka-Kuźniak, Violetta, et al.
Publicado: (2014)

Effect of methoxy stilbenes—analogs of resveratrol—on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells
por: Zielińska-Przyjemska, Małgorzata, et al.
Publicado: (2020)

The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells
por: Papierska, Katarzyna, et al.
Publicado: (2022)

Simple Amides of Oleanolic Acid as Effective Penetration Enhancers
por: Bednarczyk-Cwynar, Barbara, et al.
Publicado: (2015)

Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells
por: Paluszczak, Jarosław, et al.
Publicado: (2017)

Role of Nrf2 in Pancreatic Cancer
por: Cykowiak, Marta, et al.
Publicado: (2021)

Cannabidiol and Its Combinations with Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis and Inhibit Activation of NF-κB Signaling in Vulvar Squamous Cell Carcinoma
por: Krajka-Kuźniak, Violetta, et al.
Publicado: (2022)

Oleanolic Acid’s Semisynthetic Derivatives HIMOXOL and Br-HIMOLID Show Proautophagic Potential and Inhibit Migration of HER2-Positive Breast Cancer Cells In Vitro
por: Lisiak, Natalia Magdalena, et al.
Publicado: (2021)

R-sulforaphane modulates the expression profile of AhR, ERα, Nrf2, NQO1, and GSTP in human breast cell lines
por: Licznerska, Barbara, et al.
Publicado: (2020)

Polymorphism of Butyl Ester of Oleanolic Acid—The Dominance of Dispersive Interactions over Electrostatic
por: Langer, Dominik, et al.
Publicado: (2023)

COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells
por: Majchrzak-Celińska, Aleksandra, et al.
Publicado: (2021)

The Effect of 3′-Hydroxy-3,4,5,4′-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells
por: Nowicki, Andrzej, et al.
Publicado: (2020)

The Effect of Oleanolic Acid and Its Four New Semisynthetic Derivatives on Human MeWo and A375 Melanoma Cell Lines
por: Bednarczyk-Cwynar, Barbara, et al.
Publicado: (2023)

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines
por: Kucinska, Malgorzata, et al.
Publicado: (2018)

Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines
por: Licznerska, Barbara E., et al.
Publicado: (2012)

3,4,5,4′-trans-tetramethoxystilbene (DMU-212) modulates the activation of NF-κB, AP-1, and STAT3 transcription factors in rat liver carcinogenesis induced by initiation-promotion regimen
por: Cichocki, Michał, et al.
Publicado: (2014)

Erratum to: Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines
por: Licznerska, Barbara E., et al.
Publicado: (2014)

Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR
por: Lisiak, Natalia, et al.
Publicado: (2023)

Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin
por: Bednarczyk-Cwynar, Barbara, et al.
Publicado: (2016)

Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines
por: Piotrowska, Hanna, et al.
Publicado: (2013)

Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients
por: Majchrzak-Celińska, Aleksandra, et al.
Publicado: (2013)

Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide
por: Majchrzak-Celińska, Aleksandra, et al.
Publicado: (2022)

Saponin Fractions from Eryngium planum L. Induce Apoptosis in Ovarian SKOV-3 Cancer Cells
por: Kikowska, Małgorzata, et al.
Publicado: (2023)

Resveratrol Analogues as Selective Estrogen Signaling Pathway Modulators: Structure–Activity Relationship
por: Kobylka, Paulina, et al.
Publicado: (2022)

3′-hydroxy-3,4,5,4′-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model
por: Piotrowska-Kempisty, Hanna, et al.
Publicado: (2016)

The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential
por: Gostyńska, Aleksandra, et al.
Publicado: (2023)

Honokiol-Loaded Nanoemulsion for Glioblastoma Treatment: Statistical Optimization, Physicochemical Characterization, and an In Vitro Toxicity Assay
por: Gostyńska, Aleksandra, et al.
Publicado: (2023)

Synthesis, Cytotoxicity and Molecular Docking of New Hybrid Compounds by Combination of Curcumin with Oleanolic Acid
por: Sowa-Kasprzak, Katarzyna, et al.
Publicado: (2023)

Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity
por: Tateishi, Yasuhiro, et al.
Publicado: (2020)

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
por: Mikuła-Pietrasik, Justyna, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3icc0g7b1bu0s2es1prtpp4htq