Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A(1) and A(2A) Receptors, and Efficacy in Animal Models of Depression

New compounds with a 7-amino-2-arylmethyl-thiazolo[5,4-d]pyrimidine structure were synthesized and evaluated in vitro for their affinity and/or potency at the human (h) A(1), hA(2A), hA(2B), and hA(3) adenosine receptors (ARs). Several compounds (5, 8–10, 13, 18, 19) were characterized by nanomolar...

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Detalles Bibliográficos
Autores principales: Varano, Flavia, Catarzi, Daniela, Vigiani, Erica, Dal Ben, Diego, Buccioni, Michela, Marucci, Gabriella, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Ghelardini, Carla, Volpini, Rosaria, Colotta, Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308585/
https://www.ncbi.nlm.nih.gov/pubmed/34358083
http://dx.doi.org/10.3390/ph14070657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308585/
https://www.ncbi.nlm.nih.gov/pubmed/34358083
http://dx.doi.org/10.3390/ph14070657

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