Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)—A Necessity for Future ADC Research and Development

Biologically-based therapies increasingly rely on the endocytic cycle of internalization and exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (endosomal sorting (recycling, lysosome localization) and lateral membrane movement) are often dysfunctional in can...

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Detalles Bibliográficos
Autores principales: Hammood, Manar, Craig, Andrew W., Leyton, Jeffrey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308841/
https://www.ncbi.nlm.nih.gov/pubmed/34358100
http://dx.doi.org/10.3390/ph14070674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308841/
https://www.ncbi.nlm.nih.gov/pubmed/34358100
http://dx.doi.org/10.3390/ph14070674

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