Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening

The major cause of bacterial resistance to β-lactams is the production of hydrolytic β-lactamase enzymes. Nowadays, the combination of β-lactam antibiotics with β-lactamase inhibitors (BLIs) is the main strategy for overcoming such issues. Nevertheless, particularly challenging β-lactamases, such as...

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Detalles Bibliográficos
Autores principales: Garofalo, Barbara, Prati, Federica, Buonfiglio, Rosa, Coletta, Isabella, D’Atanasio, Noemi, Molteni, Angela, Carettoni, Daniele, Wanke, Valeria, Pochetti, Giorgio, Montanari, Roberta, Capelli, Davide, Milanese, Claudio, Di Giorgio, Francesco Paolo, Ombrato, Rosella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308845/
https://www.ncbi.nlm.nih.gov/pubmed/34202402
http://dx.doi.org/10.3390/ph14070612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308845/
https://www.ncbi.nlm.nih.gov/pubmed/34202402
http://dx.doi.org/10.3390/ph14070612

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