Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues

Site-specific antibody conjugations generate homogeneous antibody-drug conjugates with high therapeutic index. However, there are limited examples for producing the site-specific conjugates with a drug-to-antibody ratio (DAR) greater than two, especially using engineered cysteines. Based on availabl...

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Detalles Bibliográficos
Autores principales: Zhou, Qun, Kyazike, Josephine, Boudanova, Ekaterina, Drzyzga, Michael, Honey, Denise, Cost, Robert, Hou, Lihui, Duffieux, Francis, Brun, Marie-Priscille, Park, Anna, Qiu, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308878/
https://www.ncbi.nlm.nih.gov/pubmed/34358098
http://dx.doi.org/10.3390/ph14070672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308878/
https://www.ncbi.nlm.nih.gov/pubmed/34358098
http://dx.doi.org/10.3390/ph14070672

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