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Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation

Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing. In this study, discrete element method (DEM) based simulations are perfor...

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Detalles Bibliográficos
Autores principales: Kumar, Ashish, Radl, Stefan, Gernaey, Krist V., De Beer, Thomas, Nopens, Ingmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308998/
https://www.ncbi.nlm.nih.gov/pubmed/34206609
http://dx.doi.org/10.3390/pharmaceutics13070928