Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT

A recently-validated and underexplored drug target in Mycobacterium tuberculosis is PptT, an essential phosphopantetheinyl transferase (PPTase) that plays a critical role in activating enzymes for both primary and secondary metabolism. PptT possesses a deep binding pocket that does not readily accep...

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Detalles Bibliográficos
Autores principales: Brown, Alistair S., Owen, Jeremy G., Jung, James, Baker, Edward N., Ackerley, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309046/
https://www.ncbi.nlm.nih.gov/pubmed/34371757
http://dx.doi.org/10.3390/pharmaceutics13071066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309046/
https://www.ncbi.nlm.nih.gov/pubmed/34371757
http://dx.doi.org/10.3390/pharmaceutics13071066

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