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Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT

A recently-validated and underexplored drug target in Mycobacterium tuberculosis is PptT, an essential phosphopantetheinyl transferase (PPTase) that plays a critical role in activating enzymes for both primary and secondary metabolism. PptT possesses a deep binding pocket that does not readily accep...

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Detalles Bibliográficos
Autores principales:	Brown, Alistair S., Owen, Jeremy G., Jung, James, Baker, Edward N., Ackerley, David F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309046/ https://www.ncbi.nlm.nih.gov/pubmed/34371757 http://dx.doi.org/10.3390/pharmaceutics13071066

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