Cargando…

Huntingtin and Its Role in Mechanisms of RNA-Mediated Toxicity

Huntington’s disease (HD) is caused by a CAG-repeat expansion mutation in the Huntingtin (HTT) gene. It is characterized by progressive psychiatric and neurological symptoms in combination with a progressive movement disorder. Despite the ubiquitous expression of HTT, pathological changes occur quit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heinz, Annika, Nabariya, Deepti Kailash, Krauss, Sybille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310054/ https://www.ncbi.nlm.nih.gov/pubmed/34357961 http://dx.doi.org/10.3390/toxins13070487

Ejemplares similares

Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties
por: Nabariya, Deepti Kailash, et al.
Publicado: (2022)

Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin
por: Fiorillo, Annarita, et al.
Publicado: (2021)

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity
por: Cisbani, G, et al.
Publicado: (2012)

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
por: Luo, Shouqing, et al.
Publicado: (2005)

Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease
por: Seefelder, Manuel, et al.
Publicado: (2022)

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
por: Qi, Lin, et al.
Publicado: (2012)

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide
por: Song, Haikun, et al.
Publicado: (2022)

Regulatory mechanisms of incomplete huntingtin mRNA splicing
por: Neueder, Andreas, et al.
Publicado: (2018)

Amyloid-Mediated Sequestration of Essential Proteins Contributes to Mutant Huntingtin Toxicity in Yeast
por: Kochneva-Pervukhova, Natalia V., et al.
Publicado: (2012)

Role and Perspective of Molecular Simulation-Based Investigation of RNA–Ligand Interaction: From Small Molecules and Peptides to Photoswitchable RNA Binding
por: Berdnikova, Daria V., et al.
Publicado: (2021)

A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast
por: Serpionov, Genrikh V., et al.
Publicado: (2015)

Huntingtin Lowering Strategies
por: Marxreiter, Franz, et al.
Publicado: (2020)

Mechanisms of RNA-induced toxicity in CAG repeat disorders
por: Nalavade, R, et al.
Publicado: (2013)

Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
por: van der Bent, M Leontien, et al.
Publicado: (2022)

Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons
por: Xu, Fangke, et al.
Publicado: (2019)

Huntington’s Disease Protein Huntingtin Associates with its own mRNA
por: Culver, Brady P., et al.
Publicado: (2016)

The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity
por: Hackam, Abigail S., et al.
Publicado: (1998)

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity
por: Watkin, Erin E., et al.
Publicado: (2014)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation
por: Xu, Haifei, et al.
Publicado: (2017)

Transcriptional Regulation of the Huntingtin Gene
por: Thomson, Sarah B., et al.
Publicado: (2018)

Proteostasis of Huntingtin in Health and Disease
por: Koyuncu, Seda, et al.
Publicado: (2017)

Is Huntingtin Dispensable in the Adult Brain?
por: Liu, Jeh-Ping, et al.
Publicado: (2017)

A Fresh Look at Huntingtin mRNA Processing in Huntington’s Disease
por: Romo, Lindsay, et al.
Publicado: (2018)

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons
por: Ma, Bin, et al.
Publicado: (2011)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted
por: Mario Isas, J., et al.
Publicado: (2021)

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
por: Yao, Yuwei, et al.
Publicado: (2015)

Modulation of Huntingtin Toxicity by BAG1 is Dependent on an Intact BAG Domain
por: Liman, Jan, et al.
Publicado: (2010)

Huntingtin Interacting Proteins and Pathological Implications
por: Liu, Li, et al.
Publicado: (2023)

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins
por: Bonfanti, Silvia, et al.
Publicado: (2019)

Huntingtin and the Synapse
por: Barron, Jessica C., et al.
Publicado: (2021)

The MID1 Protein: A Promising Therapeutic Target in Huntington’s Disease
por: Heinz, Annika, et al.
Publicado: (2021)

Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1
por: Meriin, Anatoli B., et al.
Publicado: (2002)

Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments
por: Butler, David C., et al.
Publicado: (2011)

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
por: Liang, Qiuli, et al.
Publicado: (2011)

Sequestration of Sup35 by Aggregates of huntingtin Fragments Causes Toxicity of [PSI(+)] Yeast
por: Zhao, Xiaohong, et al.
Publicado: (2012)

Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin
por: Tang, Bor Luen
Publicado: (2018)

Cancer: From Wild-Type to Mutant Huntingtin
por: Thion, Morgane Sonia, et al.
Publicado: (2018)

A Huntingtin Peptide Inhibits PolyQ-Huntingtin Associated Defects
por: Arribat, Yoan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_n8le9id2s44lgjqgmb4i765mm2