Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop

Ebolavirus (EBOV) is a negative-sense RNA virus that causes severe hemorrhagic fever in humans. The matrix protein VP40 facilitates viral budding by binding to lipids in the host cell plasma membrane and driving the formation of filamentous, pleomorphic virus particles. The C-terminal domain of VP40...

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Detalles Bibliográficos
Autores principales: Johnson, Kristen A., Bhattarai, Nisha, Budicini, Melissa R., LaBonia, Carolyn M., Baker, Sarah Catherine B., Gerstman, Bernard S., Chapagain, Prem P., Stahelin, Robert V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310056/
https://www.ncbi.nlm.nih.gov/pubmed/34372582
http://dx.doi.org/10.3390/v13071375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310056/
https://www.ncbi.nlm.nih.gov/pubmed/34372582
http://dx.doi.org/10.3390/v13071375

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