Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely understood. Progress has been hindered by a lac...

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Detalles Bibliográficos
Autores principales: Abd El-Aziz, Tarek Mohamed, Xiao, Yucheng, Kline, Jake, Gridley, Harold, Heaston, Alyse, Linse, Klaus D., Ward, Micaiah J., Rokyta, Darin R., Stockand, James D., Cummins, Theodore R., Fornelli, Luca, Rowe, Ashlee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310189/
https://www.ncbi.nlm.nih.gov/pubmed/34357973
http://dx.doi.org/10.3390/toxins13070501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310189/
https://www.ncbi.nlm.nih.gov/pubmed/34357973
http://dx.doi.org/10.3390/toxins13070501

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