In Vitro and In Vivo Antifibrotic Effects of Fraxetin on Renal Interstitial Fibrosis via the ERK Signaling Pathway

Fraxetin, a natural derivative of coumarin, is known to have anti-inflammatory, anti-oxidant, and hepatoprotective effects in multiple diseases and in liver fibrosis. Whether fraxetin exerts similar effects against renal fibrosis is unknown. In a Unilateral Ureteral Obstruction (UUO) mouse model of...

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Detalles Bibliográficos
Autores principales: Hsieh, Yi-Hsien, Hung, Tung-Wei, Chen, Yong-Syuan, Huang, Yi-Ning, Chiou, Hui-Ling, Lee, Chu-Che, Tsai, Jen-Pi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310265/
https://www.ncbi.nlm.nih.gov/pubmed/34357946
http://dx.doi.org/10.3390/toxins13070474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310265/
https://www.ncbi.nlm.nih.gov/pubmed/34357946
http://dx.doi.org/10.3390/toxins13070474

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