Antibodies Elicited in Response to a Single Cycle Glycoprotein D Deletion Viral Vaccine Candidate Bind C1q and Activate Complement Mediated Neutralization and Cytolysis

Herpes simplex virus (HSV) prevention is a global health priority but, despite decades of research, there is no effective vaccine. Prior efforts focused on generating glycoprotein D (gD) neutralizing antibodies, but clinical trial outcomes were disappointing. The deletion of gD yields a single-cycle...

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Detalles Bibliográficos
Autores principales: Visciano, Maria Luisa, Mahant, Aakash Mahant, Pierce, Carl, Hunte, Richard, Herold, Betsy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310317/
https://www.ncbi.nlm.nih.gov/pubmed/34209320
http://dx.doi.org/10.3390/v13071284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310317/
https://www.ncbi.nlm.nih.gov/pubmed/34209320
http://dx.doi.org/10.3390/v13071284

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