Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor

The chemokine receptor CCR5 is a key player in HIV-1 infection. The cryo-EM 3D structure of HIV-1 envelope glycoprotein (Env) subunit gp120 in complex with CD4 and CCR5 has provided important structural insights into HIV-1/host cell interaction, yet it has not explained the signaling properties of E...

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Detalles Bibliográficos
Autores principales: Jacquemard, Célien, Koensgen, Florian, Colin, Philippe, Lagane, Bernard, Kellenberger, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310383/
https://www.ncbi.nlm.nih.gov/pubmed/34372601
http://dx.doi.org/10.3390/v13071395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310383/
https://www.ncbi.nlm.nih.gov/pubmed/34372601
http://dx.doi.org/10.3390/v13071395

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