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Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway

Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or Kochia scoparia) and its principle saponin, Momordin Ic, have been reported to protect ag...

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Autores principales: Luo, Meijunzi, Zeng, Bijun, Wang, Haizhen, Yang, Zhibo, Peng, Youhua, Zhang, Yujin, Wang, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310444/
https://www.ncbi.nlm.nih.gov/pubmed/34326883
http://dx.doi.org/10.1155/2021/5522164
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author Luo, Meijunzi
Zeng, Bijun
Wang, Haizhen
Yang, Zhibo
Peng, Youhua
Zhang, Yujin
Wang, Chang
author_facet Luo, Meijunzi
Zeng, Bijun
Wang, Haizhen
Yang, Zhibo
Peng, Youhua
Zhang, Yujin
Wang, Chang
author_sort Luo, Meijunzi
collection PubMed
description Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or Kochia scoparia) and its principle saponin, Momordin Ic, have been reported to protect against inflammation. Herein, we demonstrated that Momordin Ic could inhibit HaCaT cell proliferation and enhance cell apoptosis. In the meantime, Momordin Ic alters Wnt/β-catenin pathway activation by affecting β-catenin nuclear distribution. The Wnt/β-catenin signaling activator LiCl partially reversed the effects of Momordin Ic on HaCaT phenotypes and the Wnt/β-catenin pathway factors. Altogether, we demonstrate the inhibitory effects of Momordin Ic, one of the major saponin constituents of Fructus Kochiae, on HaCaT cell proliferation and Momordin Ic-induced alteration within the Wnt/β-catenin pathway. Momordin Ic might act on HaCaT cells by modulating the Wnt/β-catenin pathway.
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spelling pubmed-83104442021-07-28 Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway Luo, Meijunzi Zeng, Bijun Wang, Haizhen Yang, Zhibo Peng, Youhua Zhang, Yujin Wang, Chang Evid Based Complement Alternat Med Research Article Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or Kochia scoparia) and its principle saponin, Momordin Ic, have been reported to protect against inflammation. Herein, we demonstrated that Momordin Ic could inhibit HaCaT cell proliferation and enhance cell apoptosis. In the meantime, Momordin Ic alters Wnt/β-catenin pathway activation by affecting β-catenin nuclear distribution. The Wnt/β-catenin signaling activator LiCl partially reversed the effects of Momordin Ic on HaCaT phenotypes and the Wnt/β-catenin pathway factors. Altogether, we demonstrate the inhibitory effects of Momordin Ic, one of the major saponin constituents of Fructus Kochiae, on HaCaT cell proliferation and Momordin Ic-induced alteration within the Wnt/β-catenin pathway. Momordin Ic might act on HaCaT cells by modulating the Wnt/β-catenin pathway. Hindawi 2021-07-16 /pmc/articles/PMC8310444/ /pubmed/34326883 http://dx.doi.org/10.1155/2021/5522164 Text en Copyright © 2021 Meijunzi Luo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Luo, Meijunzi
Zeng, Bijun
Wang, Haizhen
Yang, Zhibo
Peng, Youhua
Zhang, Yujin
Wang, Chang
Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway
title Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway
title_full Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway
title_fullStr Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway
title_full_unstemmed Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway
title_short Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway
title_sort kochia scoparia saponin momordin ic modulates hacat cell proliferation and apoptosis via the wnt/β-catenin pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310444/
https://www.ncbi.nlm.nih.gov/pubmed/34326883
http://dx.doi.org/10.1155/2021/5522164
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