Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2

Rett syndrome (RTT) is a progressive neurodevelopmental disorder, mainly caused by mutations in MeCP2 and currently with no cure. We report here that neurons from R106W MeCP2 RTT human iPSCs as well as human embryonic stem cells after MeCP2 knockdown exhibit consistent and long-lasting impairment in...

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Detalles Bibliográficos
Autores principales: Chen, Xiaoying, Han, Xu, Blanchi, Bruno, Guan, Wuqiang, Ge, Weihong, Yu, Yong-Chun, Sun, Yi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310543/
https://www.ncbi.nlm.nih.gov/pubmed/32851591
http://dx.doi.org/10.1007/s13238-020-00773-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310543/
https://www.ncbi.nlm.nih.gov/pubmed/32851591
http://dx.doi.org/10.1007/s13238-020-00773-z

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