Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells

Telomerase/telomere-targeting therapy is a potentially promising approach for cancer treatment because even transient telomere dysfunction can induce chromosomal instability (CIN) and may be a barrier to tumor growth. We recently developed a dual-HAC (Human Artificial Chromosome) assay that enables...

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Detalles Bibliográficos
Autores principales: Petrov, Nikolai, Lee, Hee-Sheung, Liskovykh, Mikhail, Teulade-Fichou, Marie-Paule, Masumoto, Hiroshi, Earnshaw, William C., Pommier, Yves, Larionov, Vladimir, Kouprina, Natalay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310675/
https://www.ncbi.nlm.nih.gov/pubmed/34316326
http://dx.doi.org/10.18632/oncotarget.28020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310675/
https://www.ncbi.nlm.nih.gov/pubmed/34316326
http://dx.doi.org/10.18632/oncotarget.28020

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