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Molecular mechanisms of opioid tolerance: From opioid receptors to inflammatory mediators (Review)

Opioids are considered the most effective analgesics for the treatment of both acute and chronic pain. However, prolonged opioid use can induce a certain level of tolerance to its analgesic effects, leading to a reduction in its effectiveness, addiction and abuse. A better understanding of the mecha...

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Detalles Bibliográficos
Autores principales: Zhou, Jie, Ma, Ruijie, Jin, Ying, Fang, Junfan, Du, Junying, Shao, Xiaomei, Liang, Yi, Fang, Jianqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311239/
https://www.ncbi.nlm.nih.gov/pubmed/34345286
http://dx.doi.org/10.3892/etm.2021.10437