Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System

Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully op...

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Autores principales: Sellers, Kristin K., Gilron, Ro’ee, Anso, Juan, Louie, Kenneth H., Shirvalkar, Prasad R., Chang, Edward F., Little, Simon J., Starr, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312257/
https://www.ncbi.nlm.nih.gov/pubmed/34322004
http://dx.doi.org/10.3389/fnhum.2021.714256
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author Sellers, Kristin K.
Gilron, Ro’ee
Anso, Juan
Louie, Kenneth H.
Shirvalkar, Prasad R.
Chang, Edward F.
Little, Simon J.
Starr, Philip A.
author_facet Sellers, Kristin K.
Gilron, Ro’ee
Anso, Juan
Louie, Kenneth H.
Shirvalkar, Prasad R.
Chang, Edward F.
Little, Simon J.
Starr, Philip A.
author_sort Sellers, Kristin K.
collection PubMed
description Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully optimize therapy for patients implanted with these devices, analyses must be conducted offline on the recorded neural data, in order to inform optimal sense and stimulation parameters. The file format, volume, and complexity of raw data from these devices necessitate conversion, parsing, and time reconstruction ahead of time-frequency analyses and modeling common to standard neuroscientific analyses. Here, we provide an open-source toolbox written in Matlab which takes raw files from the Summit RC+S and transforms these data into a standardized format amenable to conventional analyses. Furthermore, we provide a plotting tool which can aid in the visualization of multiple data streams and sense, stimulation, and therapy settings. Finally, we describe an analysis module which replicates RC+S on-board power computations, a functionality which can accelerate biomarker discovery. This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses.
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spelling pubmed-83122572021-07-27 Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System Sellers, Kristin K. Gilron, Ro’ee Anso, Juan Louie, Kenneth H. Shirvalkar, Prasad R. Chang, Edward F. Little, Simon J. Starr, Philip A. Front Hum Neurosci Neuroscience Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully optimize therapy for patients implanted with these devices, analyses must be conducted offline on the recorded neural data, in order to inform optimal sense and stimulation parameters. The file format, volume, and complexity of raw data from these devices necessitate conversion, parsing, and time reconstruction ahead of time-frequency analyses and modeling common to standard neuroscientific analyses. Here, we provide an open-source toolbox written in Matlab which takes raw files from the Summit RC+S and transforms these data into a standardized format amenable to conventional analyses. Furthermore, we provide a plotting tool which can aid in the visualization of multiple data streams and sense, stimulation, and therapy settings. Finally, we describe an analysis module which replicates RC+S on-board power computations, a functionality which can accelerate biomarker discovery. This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses. Frontiers Media S.A. 2021-07-12 /pmc/articles/PMC8312257/ /pubmed/34322004 http://dx.doi.org/10.3389/fnhum.2021.714256 Text en Copyright © 2021 Sellers, Gilron, Anso, Louie, Shirvalkar, Chang, Little and Starr. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sellers, Kristin K.
Gilron, Ro’ee
Anso, Juan
Louie, Kenneth H.
Shirvalkar, Prasad R.
Chang, Edward F.
Little, Simon J.
Starr, Philip A.
Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
title Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
title_full Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
title_fullStr Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
title_full_unstemmed Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
title_short Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
title_sort analysis-rcs-data: open-source toolbox for the ingestion, time-alignment, and visualization of sense and stimulation data from the medtronic summit rc+s system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312257/
https://www.ncbi.nlm.nih.gov/pubmed/34322004
http://dx.doi.org/10.3389/fnhum.2021.714256
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