Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System
Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully op...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312257/ https://www.ncbi.nlm.nih.gov/pubmed/34322004 http://dx.doi.org/10.3389/fnhum.2021.714256 |
_version_ | 1783729112904368128 |
---|---|
author | Sellers, Kristin K. Gilron, Ro’ee Anso, Juan Louie, Kenneth H. Shirvalkar, Prasad R. Chang, Edward F. Little, Simon J. Starr, Philip A. |
author_facet | Sellers, Kristin K. Gilron, Ro’ee Anso, Juan Louie, Kenneth H. Shirvalkar, Prasad R. Chang, Edward F. Little, Simon J. Starr, Philip A. |
author_sort | Sellers, Kristin K. |
collection | PubMed |
description | Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully optimize therapy for patients implanted with these devices, analyses must be conducted offline on the recorded neural data, in order to inform optimal sense and stimulation parameters. The file format, volume, and complexity of raw data from these devices necessitate conversion, parsing, and time reconstruction ahead of time-frequency analyses and modeling common to standard neuroscientific analyses. Here, we provide an open-source toolbox written in Matlab which takes raw files from the Summit RC+S and transforms these data into a standardized format amenable to conventional analyses. Furthermore, we provide a plotting tool which can aid in the visualization of multiple data streams and sense, stimulation, and therapy settings. Finally, we describe an analysis module which replicates RC+S on-board power computations, a functionality which can accelerate biomarker discovery. This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses. |
format | Online Article Text |
id | pubmed-8312257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83122572021-07-27 Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System Sellers, Kristin K. Gilron, Ro’ee Anso, Juan Louie, Kenneth H. Shirvalkar, Prasad R. Chang, Edward F. Little, Simon J. Starr, Philip A. Front Hum Neurosci Neuroscience Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully optimize therapy for patients implanted with these devices, analyses must be conducted offline on the recorded neural data, in order to inform optimal sense and stimulation parameters. The file format, volume, and complexity of raw data from these devices necessitate conversion, parsing, and time reconstruction ahead of time-frequency analyses and modeling common to standard neuroscientific analyses. Here, we provide an open-source toolbox written in Matlab which takes raw files from the Summit RC+S and transforms these data into a standardized format amenable to conventional analyses. Furthermore, we provide a plotting tool which can aid in the visualization of multiple data streams and sense, stimulation, and therapy settings. Finally, we describe an analysis module which replicates RC+S on-board power computations, a functionality which can accelerate biomarker discovery. This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses. Frontiers Media S.A. 2021-07-12 /pmc/articles/PMC8312257/ /pubmed/34322004 http://dx.doi.org/10.3389/fnhum.2021.714256 Text en Copyright © 2021 Sellers, Gilron, Anso, Louie, Shirvalkar, Chang, Little and Starr. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Sellers, Kristin K. Gilron, Ro’ee Anso, Juan Louie, Kenneth H. Shirvalkar, Prasad R. Chang, Edward F. Little, Simon J. Starr, Philip A. Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System |
title | Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System |
title_full | Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System |
title_fullStr | Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System |
title_full_unstemmed | Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System |
title_short | Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System |
title_sort | analysis-rcs-data: open-source toolbox for the ingestion, time-alignment, and visualization of sense and stimulation data from the medtronic summit rc+s system |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312257/ https://www.ncbi.nlm.nih.gov/pubmed/34322004 http://dx.doi.org/10.3389/fnhum.2021.714256 |
work_keys_str_mv | AT sellerskristink analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT gilronroee analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT ansojuan analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT louiekennethh analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT shirvalkarprasadr analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT changedwardf analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT littlesimonj analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem AT starrphilipa analysisrcsdataopensourcetoolboxfortheingestiontimealignmentandvisualizationofsenseandstimulationdatafromthemedtronicsummitrcssystem |