α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice

Inflammation and extracellular matrix (ECM) degradation have been implicated in the pathological process of osteoarthritis (OA). α-Cyperone is the main active component of the traditional Chinese medicine Cyperus rotundus L. In this study, we found that α-Cyperone abolished the IL-1β-induced product...

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Detalles Bibliográficos
Autores principales: Zhang, Huawei, Li, Sunlong, Lu, Jiajie, Jin, Jie, Zhu, Gaosheng, Wang, Libo, Yan, Yingzhao, He, Linjie, Wang, Ben, Wang, Xiangyang, Yu, Huachen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312409/
https://www.ncbi.nlm.nih.gov/pubmed/34237707
http://dx.doi.org/10.18632/aging.203259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312409/
https://www.ncbi.nlm.nih.gov/pubmed/34237707
http://dx.doi.org/10.18632/aging.203259

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