Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43

Aberrant expression and denaturation of Tau, amyloid-beta and TDP-43 can lead to cell death and is a major component of pathologies such as Alzheimer’s Disease (AD). AD neurons exhibit a reduced ability to form autophagosomes and degrade proteins via autophagy. Using genetically manipulated colon ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Dent, Paul, Booth, Laurence, Roberts, Jane L., Poklepovic, Andrew, Cridebring, Derek, Reiman, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312464/
https://www.ncbi.nlm.nih.gov/pubmed/34252884
http://dx.doi.org/10.18632/aging.203297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312464/
https://www.ncbi.nlm.nih.gov/pubmed/34252884
http://dx.doi.org/10.18632/aging.203297

Ejemplares similares