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Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43

Aberrant expression and denaturation of Tau, amyloid-beta and TDP-43 can lead to cell death and is a major component of pathologies such as Alzheimer’s Disease (AD). AD neurons exhibit a reduced ability to form autophagosomes and degrade proteins via autophagy. Using genetically manipulated colon ca...

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Detalles Bibliográficos
Autores principales:	Dent, Paul, Booth, Laurence, Roberts, Jane L., Poklepovic, Andrew, Cridebring, Derek, Reiman, Eric M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312464/ https://www.ncbi.nlm.nih.gov/pubmed/34252884 http://dx.doi.org/10.18632/aging.203297

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