Mechanistic Investigations Support Liver Safety of Ubrogepant

Small-molecule calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated therapeutic efficacy for the treatment of migraine. However, previously investigated CGRP receptor antagonists, telcagepant and MK-3207, were discontinued during clinical development because of concerns abou...

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Detalles Bibliográficos
Autores principales: Smith, Brenda, Rowe, Josh, Watkins, Paul B, Ashina, Messoud, Woodhead, Jeffrey L, Sistare, Frank D, Goadsby, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Clinical and Translational Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312697/
https://www.ncbi.nlm.nih.gov/pubmed/32579200
http://dx.doi.org/10.1093/toxsci/kfaa093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312697/
https://www.ncbi.nlm.nih.gov/pubmed/32579200
http://dx.doi.org/10.1093/toxsci/kfaa093

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