Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development

Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are simply calculated linearly based on the body weight, age, and body surface area of adults. Due to the ontogeny of children, this simple linear scaling may lead to drug overdose in pediatric patients. The phys...

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Detalles Bibliográficos
Autores principales: Wang, Kefei, Jiang, Kun, Wei, Xiaoyi, Li, Yulan, Wang, Tiejie, Song, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312709/
https://www.ncbi.nlm.nih.gov/pubmed/34312742
http://dx.doi.org/10.1208/s12249-021-02076-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312709/
https://www.ncbi.nlm.nih.gov/pubmed/34312742
http://dx.doi.org/10.1208/s12249-021-02076-w

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