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The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells
Iron and other transition metals, such as copper and manganese, are essential for supporting brain function, yet over-accumulation is cytotoxic. This over-accumulation of metals, particularly iron, is common to several neurological disorders; these include Alzheimer’s disease, Parkinson’s disease, F...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312958/ https://www.ncbi.nlm.nih.gov/pubmed/34310628 http://dx.doi.org/10.1371/journal.pone.0254794 |