A Brownian ratchet model for DNA loop extrusion by the cohesin complex

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational chan...

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Detalles Bibliográficos
Autores principales: Higashi, Torahiko L, Pobegalov, Georgii, Tang, Minzhe, Molodtsov, Maxim I, Uhlmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313234/
https://www.ncbi.nlm.nih.gov/pubmed/34309513
http://dx.doi.org/10.7554/eLife.67530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313234/
https://www.ncbi.nlm.nih.gov/pubmed/34309513
http://dx.doi.org/10.7554/eLife.67530

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