Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10

Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant CD8(+) tumor-infiltrating lymphocytes (TILs) responding to the abundant neoantigens from their unstable genomes. Priming of such tumor-targeted TILs first requires recruitment of CD8(+) T cells into the tumors, implyi...

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Detalles Bibliográficos
Autores principales: Mowat, Courtney, Mosley, Shayla R., Namdar, Afshin, Schiller, Daniel, Baker, Kristi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313406/
https://www.ncbi.nlm.nih.gov/pubmed/34297038
http://dx.doi.org/10.1084/jem.20210108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313406/
https://www.ncbi.nlm.nih.gov/pubmed/34297038
http://dx.doi.org/10.1084/jem.20210108

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