Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways

ABSTRACT: The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of ischemic neurons following middle cerebral artery occlusion with reperfusion (MCAO). Intracerebroventricular infusion of pioglitazone...

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Detalles Bibliográficos
Autores principales: Zhao, Yi, Lützen, Ulf, Gohlke, Peter, Jiang, Ping, Herdegen, Thomas, Culman, Juraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313471/
https://www.ncbi.nlm.nih.gov/pubmed/33864097
http://dx.doi.org/10.1007/s00109-021-02065-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313471/
https://www.ncbi.nlm.nih.gov/pubmed/33864097
http://dx.doi.org/10.1007/s00109-021-02065-3

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