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Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways
ABSTRACT: The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of ischemic neurons following middle cerebral artery occlusion with reperfusion (MCAO). Intracerebroventricular infusion of pioglitazone...
Autores principales: | Zhao, Yi, Lützen, Ulf, Gohlke, Peter, Jiang, Ping, Herdegen, Thomas, Culman, Juraj |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313471/ https://www.ncbi.nlm.nih.gov/pubmed/33864097 http://dx.doi.org/10.1007/s00109-021-02065-3 |
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