Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm originating from the pleura. Non-epithelioid (biphasic and sarcomatoid) MPM are particularly resistant to therapy. We investigated the role of the GITR-GITRL pathway in mediating the resistance to therapy. We found that GITR and GITRL ex...

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Detalles Bibliográficos
Autores principales: Chan, Meilin, Wu, Licun, Yun, Zhihong, McKee, Trevor D., Cabanero, Michael, Zhao, Yidan, Kohno, Mikihiro, Murakami, Junichi, de Perrot, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313521/
https://www.ncbi.nlm.nih.gov/pubmed/34312483
http://dx.doi.org/10.1038/s42003-021-02430-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313521/
https://www.ncbi.nlm.nih.gov/pubmed/34312483
http://dx.doi.org/10.1038/s42003-021-02430-5

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