Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts

Gain-of-function Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25% of lung adenocarcinomas, and these tumors are challenging to treat. Some preclinical work, largely based on cell lines, suggested KRAS(mut) lung cancers are especially dependent on the nuclear export protein ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosen, Joshua C., Weiss, Jessica, Pham, Nhu-An, Li, Quan, Martins-Filho, Sebastiao N., Wang, Yuhui, Tsao, Ming-Sound, Moghal, Nadeem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313753/
https://www.ncbi.nlm.nih.gov/pubmed/34284202
http://dx.doi.org/10.1016/j.tranon.2021.101179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313753/
https://www.ncbi.nlm.nih.gov/pubmed/34284202
http://dx.doi.org/10.1016/j.tranon.2021.101179

Ejemplares similares