NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice

Background: The pathogenesis of sepsis-associated encephalopathy (SAE) is complicated, while the efficacy of current treatment technologies is poor. Therefore, the discovery of related targets and the development of new drugs are essential. Methods: A mouse model of SAE was constructed by intraperit...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Qing, Wenxiang, Yi, Zexiong, Lin, Guoxin, Peng, Qianyi, Zhou, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313765/
https://www.ncbi.nlm.nih.gov/pubmed/34327209
http://dx.doi.org/10.3389/fnut.2021.701760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313765/
https://www.ncbi.nlm.nih.gov/pubmed/34327209
http://dx.doi.org/10.3389/fnut.2021.701760

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