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Linkage of nanosecond protein motion with enzymatic methyl transfer by nicotinamide N-methyltransferase

Nicotinamide N-methyltransferase (NNMT), a key cytoplasmic protein in the human body, is accountable to catalyze the nicotinamide (NCA) N(1)-methylation through S-adenosyl-L-methionine (SAM) as a methyl donor, which has been linked to many diseases. Although extensive studies have concerned about th...

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Detalles Bibliográficos
Autores principales: JING, Yahui, CHENG, Yiting, LI, Fangya, LI, Yuping, LIU, Fan, ZHANG, Jianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313939/
https://www.ncbi.nlm.nih.gov/pubmed/34377057
http://dx.doi.org/10.3906/biy-2101-54