DeTOKI identifies and characterizes the dynamics of chromatin TAD-like domains in a single cell

Topologically associating domains (TAD) are a key structure of the 3D mammalian genomes. However, the prevalence and dynamics of TAD-like domains in single cells remain elusive. Here we develop a new algorithm, named deTOKI, to decode TAD-like domains with single-cell Hi-C data. By non-negative matr...

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Detalles Bibliográficos
Autores principales: Li, Xiao, Zeng, Guangjie, Li, Angsheng, Zhang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314462/
https://www.ncbi.nlm.nih.gov/pubmed/34311744
http://dx.doi.org/10.1186/s13059-021-02435-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314462/
https://www.ncbi.nlm.nih.gov/pubmed/34311744
http://dx.doi.org/10.1186/s13059-021-02435-7

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