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DeTOKI identifies and characterizes the dynamics of chromatin TAD-like domains in a single cell
Topologically associating domains (TAD) are a key structure of the 3D mammalian genomes. However, the prevalence and dynamics of TAD-like domains in single cells remain elusive. Here we develop a new algorithm, named deTOKI, to decode TAD-like domains with single-cell Hi-C data. By non-negative matr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314462/ https://www.ncbi.nlm.nih.gov/pubmed/34311744 http://dx.doi.org/10.1186/s13059-021-02435-7 |