Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

The pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD. Farnesyltransferase (FT) catalyzes a key posttranslational modification process called farnesylation, in which the isoprenoid farnesyl py...

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Detalles Bibliográficos
Autores principales: Jeong, Angela, Cheng, Shaowu, Zhong, Rui, Bennett, David A., Bergö, Martin O., Li, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314463/
https://www.ncbi.nlm.nih.gov/pubmed/34315531
http://dx.doi.org/10.1186/s40478-021-01231-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314463/
https://www.ncbi.nlm.nih.gov/pubmed/34315531
http://dx.doi.org/10.1186/s40478-021-01231-5

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