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Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later

BACKGROUND: The PEPaNIC multicenter randomized controlled trial (RCT) has shown that early administration of supplemental parenteral nutrition (early-PN) as compared with withholding PN for 1 week (late-PN) induced long-term internalizing, externalizing and total emotional/behavioral problems in cri...

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Detalles Bibliográficos
Autores principales: Jacobs, An, Güiza, Fabian, Verlinden, Ines, Dulfer, Karolijn, Garcia Guerra, Gonzalo, Joosten, Koen, Verbruggen, Sascha C., Vanhorebeek, Ilse, Van den Berghe, Greet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314560/
https://www.ncbi.nlm.nih.gov/pubmed/34315515
http://dx.doi.org/10.1186/s13148-021-01124-3