The Spleen Tyrosine Kinase Inhibitor, Entospletinib (GS-9973) Restores Chemosensitivity in Lung Cancer Cells by Modulating ABCG2-mediated Multidrug Resistance

Tyrosine kinase inhibitors (TKIs) are important in managing lymphoid malignancies by targeting B-cell receptor signaling pathways. Entospletinib (GS-9973) is an oral, selective inhibitor of spleen tyrosine kinase (Syk), currently in the phase II clinical trials for the treatment of chronic lymphocyt...

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Detalles Bibliográficos
Autores principales: Narayanan, Silpa, Wu, Zhuo-Xun, Wang, Jing-Quan, Ma, Hansu, Acharekar, Nikita, Koya, Jagadish, Yoganathan, Sabesan, Fang, Shuo, Chen, Zhe-Sheng, Pan, Yihang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315011/
https://www.ncbi.nlm.nih.gov/pubmed/34326700
http://dx.doi.org/10.7150/ijbs.61229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315011/
https://www.ncbi.nlm.nih.gov/pubmed/34326700
http://dx.doi.org/10.7150/ijbs.61229

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