Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer

Rationale: The progression of prostate cancer (PCa) to castration-resistant PCa (CRPC) despite continuous androgen deprivation therapy is a major clinical challenge. Over 90% of patients with CRPC exhibit sustained androgen receptor (AR) signaling. KDM4B that removes the repressive mark H3K9me3/2 is...

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Detalles Bibliográficos
Autores principales: Wu, Meng-Jen, Chen, Chih-Jung, Lin, Ting-Yu, Liu, Ying-Yuan, Tseng, Lin-Lu, Cheng, Mei-Ling, Chuu, Chih-Pin, Tsai, Huai-Kuang, Kuo, Wen-Ling, Kung, Hsing-Jien, Wang, Wen-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315051/
https://www.ncbi.nlm.nih.gov/pubmed/34335964
http://dx.doi.org/10.7150/thno.58729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315051/
https://www.ncbi.nlm.nih.gov/pubmed/34335964
http://dx.doi.org/10.7150/thno.58729

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