Cargando…
Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8(+) T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The inductio...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315546/ https://www.ncbi.nlm.nih.gov/pubmed/34326844 http://dx.doi.org/10.3389/fimmu.2021.693054 |
_version_ | 1783729741388316672 |
---|---|
author | Gallerani, Eleonora Proietto, Davide Dallan, Beatrice Campagnaro, Marco Pacifico, Salvatore Albanese, Valentina Marzola, Erika Marconi, Peggy Caputo, Antonella Appay, Victor Gavioli, Riccardo Nicoli, Francesco |
author_facet | Gallerani, Eleonora Proietto, Davide Dallan, Beatrice Campagnaro, Marco Pacifico, Salvatore Albanese, Valentina Marzola, Erika Marconi, Peggy Caputo, Antonella Appay, Victor Gavioli, Riccardo Nicoli, Francesco |
author_sort | Gallerani, Eleonora |
collection | PubMed |
description | Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8(+) T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8(+) T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8(+) T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8(+) T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8(+) T-cell responses. |
format | Online Article Text |
id | pubmed-8315546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83155462021-07-28 Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects Gallerani, Eleonora Proietto, Davide Dallan, Beatrice Campagnaro, Marco Pacifico, Salvatore Albanese, Valentina Marzola, Erika Marconi, Peggy Caputo, Antonella Appay, Victor Gavioli, Riccardo Nicoli, Francesco Front Immunol Immunology Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8(+) T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8(+) T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8(+) T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8(+) T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8(+) T-cell responses. Frontiers Media S.A. 2021-07-13 /pmc/articles/PMC8315546/ /pubmed/34326844 http://dx.doi.org/10.3389/fimmu.2021.693054 Text en Copyright © 2021 Gallerani, Proietto, Dallan, Campagnaro, Pacifico, Albanese, Marzola, Marconi, Caputo, Appay, Gavioli and Nicoli https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gallerani, Eleonora Proietto, Davide Dallan, Beatrice Campagnaro, Marco Pacifico, Salvatore Albanese, Valentina Marzola, Erika Marconi, Peggy Caputo, Antonella Appay, Victor Gavioli, Riccardo Nicoli, Francesco Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |
title | Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |
title_full | Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |
title_fullStr | Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |
title_full_unstemmed | Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |
title_short | Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |
title_sort | impaired priming of sars-cov-2-specific naive cd8(+) t cells in older subjects |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315546/ https://www.ncbi.nlm.nih.gov/pubmed/34326844 http://dx.doi.org/10.3389/fimmu.2021.693054 |
work_keys_str_mv | AT galleranieleonora impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT proiettodavide impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT dallanbeatrice impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT campagnaromarco impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT pacificosalvatore impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT albanesevalentina impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT marzolaerika impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT marconipeggy impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT caputoantonella impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT appayvictor impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT gavioliriccardo impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects AT nicolifrancesco impairedprimingofsarscov2specificnaivecd8tcellsinoldersubjects |