KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associated herpesvirus (KSHV) infected cells maintains replication i...

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Detalles Bibliográficos
Autores principales: Kumar Singh, Rajnish, Pei, Yonggang, Bose, Dipayan, Lamplugh, Zachary L, Sun, Kunfeng, Yuan, Yan, Lieberman, Paul, You, Jianxin, Robertson, Erle S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315796/
https://www.ncbi.nlm.nih.gov/pubmed/34279223
http://dx.doi.org/10.7554/eLife.57436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315796/
https://www.ncbi.nlm.nih.gov/pubmed/34279223
http://dx.doi.org/10.7554/eLife.57436

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