Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival. Yet, some MLL-rearranged leukemias are inexplica...

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Detalles Bibliográficos
Autores principales: Richter, William F, Shah, Rohan N, Ruthenburg, Alexander J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315800/
https://www.ncbi.nlm.nih.gov/pubmed/34263728
http://dx.doi.org/10.7554/eLife.64960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315800/
https://www.ncbi.nlm.nih.gov/pubmed/34263728
http://dx.doi.org/10.7554/eLife.64960

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