Cargando…
Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia
MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival. Yet, some MLL-rearranged leukemias are inexplica...
Autores principales: | Richter, William F, Shah, Rohan N, Ruthenburg, Alexander J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315800/ https://www.ncbi.nlm.nih.gov/pubmed/34263728 http://dx.doi.org/10.7554/eLife.64960 |
Ejemplares similares
-
Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias
por: Yi, Yan, et al.
Publicado: (2022) -
MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
por: Benito, Juliana M., et al.
Publicado: (2015) -
Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions
por: Chan, Anthony K. N., et al.
Publicado: (2019) -
RNA binding proteins in MLL-rearranged leukemia
por: Tran, Tiffany M., et al.
Publicado: (2022) -
Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement
por: Zhang, Hao, et al.
Publicado: (2019)