RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

Upon viral RNA recognition, the RIG-I signalosome continuously generates IFNs and cytokines, leading to neutrophil recruitment and inflammation. Thus, attenuation of excessive immune and inflammatory responses is crucial to restore immune homeostasis and prevent unwarranted damage, yet few resolving...

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Detalles Bibliográficos
Autores principales: Yang, Ziwei, Wang, Jun, He, Bailin, Zhang, Xiaolin, Li, Xiaojuan, Kuang, Ersheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315805/
https://www.ncbi.nlm.nih.gov/pubmed/34313226
http://dx.doi.org/10.7554/eLife.68958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315805/
https://www.ncbi.nlm.nih.gov/pubmed/34313226
http://dx.doi.org/10.7554/eLife.68958

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