Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to isoniazid and rifampin (i.e., multidrug resistance [MDR]) and is conferred by loss-of-function pncA mutations that inhibit...

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Detalles Bibliográficos
Autores principales: Modlin, Samuel J., Marbach, Tyler, Werngren, Jim, Mansjö, Mikael, Hoffner, Sven E., Valafar, Faramarz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315952/
https://www.ncbi.nlm.nih.gov/pubmed/33722890
http://dx.doi.org/10.1128/AAC.01916-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315952/
https://www.ncbi.nlm.nih.gov/pubmed/33722890
http://dx.doi.org/10.1128/AAC.01916-20

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