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Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to isoniazid and rifampin (i.e., multidrug resistance [MDR]) and is conferred by loss-of-function pncA mutations that inhibit...

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Detalles Bibliográficos
Autores principales:	Modlin, Samuel J., Marbach, Tyler, Werngren, Jim, Mansjö, Mikael, Hoffner, Sven E., Valafar, Faramarz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315952/ https://www.ncbi.nlm.nih.gov/pubmed/33722890 http://dx.doi.org/10.1128/AAC.01916-20

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